La valeur prédictive et pronostique d'une faible expression des récepteurs d'oestrogènes en cancer du sein
|Advisor:||Diorio, Caroline; Provencher, Louise|
|Abstract:||The objective of this project was to evaluate the effect of antihormonal therapy (AT) on patients with weakly positive ER breast cancers (BC) (< 10 fmol/mg of cytosol). We identified 2221 BC patients with ER tested by ligand-based assay (LBA) from 1976 to 1995, treated and followed until 2008. Cox proportional hazards models were used to assess the effect of ER levels on BC survival in patients who received AT. Of 2221 patients studied, 661 (29.8%) received AT. Of those who received AT, there was a significant risk reduction in breast cancer-specific mortality only for patients with ER levels ≥10 fmol/mg of cytosol. Therefore our results do not support treating with AT weakly positive ER BC patients identified by LBA.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||24 April 2018|
|Collection:||Thèses et mémoires|
All documents in CorpusUL are protected by Copyright Act of Canada.