La valeur pronostique de la protéine S-100B et de l'énolase neurone-spécifique suivant un traumatisme craniocérébral modéré ou grave : revues systématiques et méta-analyses
|Advisor:||Turgeon-Fournier, Alexis; Lauzier, François|
|Abstract:||The main objective of this study is to determine the prognostic value of S-100ß protein and neuron-specific enolase (NSE) following a moderate or severe traumatic brain injury (TBI). Two systematic reviews and meta-analysis were performed to find the studies having evaluated the link between a level of those biomarkers and the mortality or the Glasgow outcome scale (GOS). Of the 9228 citations, 41 and 26 studies were finally included respectively for S-100ß protein and NSE. We observed a significant association between blood levels of S-100ß protein and NSE and an unfavorable outcome such as the mortality or the GOS ≤ 3. A 100% specificity serum level threshold for mortality was between 1.38 to 10.50 µg/L for the S-100ß protein. The association showed consistent results despite the presence of significant extracranial injuries.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||24 April 2018|
|Collection:||Thèses et mémoires|
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