Mémoire de source, propension à halluciner et psychose : identification de marqueurs cognitifs et cliniques chez une population à haut risque génétique
|Abstract:||Cognitive deficits are at the core of psychosis and are observed before the onset of the disease. Episodic memory deficits are frequently reported to be among the most severe impairments, both in patients and in at risk populations. In psychotic patients, a refined analysis of episodic memory within a neuropsychological framework allowed for a better understanding of the specific altered processes. Previous studies of psychotic patients showed dysfunctions of source memory processes, which are responsible for the attribution of memories to their specific origin, that were associated with psychotic positive symptoms, especially hallucinations. However, source memory processes and subclinical hallucinatory-like experiences have never been studied before the onset of psychosis in offspring at genetic high risk of psychosis (GHR). It is still unknown if source memory alterations and subclinical symptoms appear at the onset of psychosis or if they precede it, therefore being an early marker of risk. To address this issue, three main objectives were pursued in the present thesis: 1) to examine if an alteration of source memory precede the onset of psychosis by characterizing source memory functioning in GHR, 2) to assess if subclinical hallucinatory-like experiences are present in this at-risk population and 3) to evaluate if source memory and hallucinatory experiences are associated in a GHR population, as seen in patients. Findings of the thesis showed that GHR have impaired source memory functioning, specifically in the retrieving of the temporal context of souvenirs, and present memory distortions as showed by an alteration in the binding of memories and in metacognition processes. It was also observed that GHR experience hallucinatory-like experiences more frequently than controls. Associations were found between hallucination proneness and distortions in source memory. Those results contribute to the identification of new cognitive and clinical markers of psychosis and suggest a specific association between the attribution of internal-external source of information and the development of psychosis. Empirical, theoretical, methodological and clinical contributions of this thesis are discussed.|
|Document Type:||Thèse de doctorat|
|Open Access Date:||24 April 2018|
|Collection:||Thèses et mémoires|
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