Étude comparative des déterminants métaboliques de la taille et du nombre de particules LDL chez l’homme et la femme
|Advisor:||Lamarche, Benoît; Couture, Patrick|
|Abstract:||Cardiovascular diseases (CVD) represent one of the leading mortality causes in the world. Reduction of the concentration of cholesterol in low-density-lipoprotein (LDL) is currently the privileged CVD prevention method. However, others markers such as apolipoprotein (apo) B-100 and LDL size might be more accurate in CVD risk prediction because they reflect additional features of cardiometabolic risk that are not provided by the traditional LDL-C measures in clinic. It is therefore of great interest to better understand the metabolic factors responsible for increased LDL particle number and decreased LDL particle size, in the optics of establishing an efficient prevention strategy. This thesis presents the results of an observational study, which has the objective of comparing the metabolic origins of high levels of apo-B100 and of small LDL particle size. Results suggest that both features are the result of distinct metabolic pathways.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||23 April 2018|
|Collection:||Thèses et mémoires|
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