Synthèse de nanoparticules magnétiques en milieu aqueux par plasma à pression atmosphérique : applications comme agent de contraste en imagerie par résonance magnétique

Authors: Létourneau, Mathieu
Advisor: Fortin, Marc-AndréLaroche, Gaétan
Abstract: Ultra-small iron oxide and hydroxide nanoparticles can be used to enhance vascular signal in magnetic resonance imaging. In this project, ultra small iron hydroxide magnetic nanoparticles (< 10 nm) are synthesized with a plasma-liquid electrochemical method. Rapid and simple (t < 5 min.), this technique consists of an argon microplasma directed to an aqueous solution containing metal ions and ligand molecules. Synthesizing nanoparticles directly in water is advantageous in the context of biomedical applications. After purification with size-exclusion chromatography or dialysis, the nanoparticle suspension allowed to obtain positive contrast enhancement in MRI. Finally, the prepared nanoparticles were injected in vivo (in the mouse model) enabling a high increase of vascular signal. This technology could be favourably installed in hospitals, in order to produce a biocompatible MRI contrast agent, on site and on demand.
Document Type: Mémoire de maîtrise
Issue Date: 2015
Open Access Date: 23 April 2018
Grantor: Université Laval
Collection:Thèses et mémoires

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