Les facteurs solubles sécrétés par les cellules B en réponse à Leishmania infantum et leurs effets sur la réplication du VIH-1
|Advisor:||Tremblay, Michel J.; Richard, Dave|
|Abstract:||The number of HIV-1/Leishmania co-infections is increasing in areas of endemicity. Visceral leishmaniasis is often caused by Leishmania infantum and is characterized by an uncontrolled parasitization of viscera. In this study, we exposed B cells from human tonsils to amastigotes of Leishmania infantum and observed an upregulation in the expression of several activation markers as well as a dose-dependent increase in the secretion of IL-10. Conditioned media from cultures of B cells exposed to Leishmania had an inhibitory effect on the activation of CD4+ T lymphocytes and on HIV-1 replication in these cells. Thus, the exposure of B cells to Leishmania promote their activation and induces the secretion of soluble factors with regulating properties that modulate replication of HIV-1 in CD4+ T cell.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||23 April 2018|
|Collection:||Thèses et mémoires|
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