Les facteurs solubles sécrétés par les cellules B en réponse à Leishmania infantum et leurs effets sur la réplication du VIH-1

Authors: Menasria, Rym
Advisor: Tremblay, Michel J.Richard, Dave
Abstract: The number of HIV-1/Leishmania co-infections is increasing in areas of endemicity. Visceral leishmaniasis is often caused by Leishmania infantum and is characterized by an uncontrolled parasitization of viscera. In this study, we exposed B cells from human tonsils to amastigotes of Leishmania infantum and observed an upregulation in the expression of several activation markers as well as a dose-dependent increase in the secretion of IL-10. Conditioned media from cultures of B cells exposed to Leishmania had an inhibitory effect on the activation of CD4+ T lymphocytes and on HIV-1 replication in these cells. Thus, the exposure of B cells to Leishmania promote their activation and induces the secretion of soluble factors with regulating properties that modulate replication of HIV-1 in CD4+ T cell.
Document Type: Mémoire de maîtrise
Issue Date: 2014
Open Access Date: 23 April 2018
Permalink: http://hdl.handle.net/20.500.11794/26247
Grantor: Université Laval
Collection:Thèses et mémoires

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