Caractérisation des voies alternatives de sécrétion des protéines S100A8/A9 et S100A12 par les neutrophiles humains

Authors: Chapeton Montes, Julie Andrea
Advisor: Tessier, PhilippeGilbert, Caroline
Abstract: Although S100A8/A9 (calprotectin) and S100A12 proteins expressed by neutrophils lack a signal peptide, they are found in the serum of patients with various inflammatory diseases. However, the mechanisms of secretion and the agonists that promote their secretion are still unknown. We hypothesized that several alternative secretory pathways and several agonists of neutrophils may participate in the release of S100A8/A9 and S100A12 protein. Initially, we studied the stimuli inducing the secretion of calprotectin and / or S100A12. In a second part, we were interested in signals and alternative mechanisms of secretion involved in the release of the calprotectin and S100A12. In conclusion, this study shows the complexity of alternative secretion pathways involved in S100 secretion and that these pathways are influenced by the activation of neutrophils by various agonists.
Document Type: Mémoire de maîtrise
Issue Date: 2015
Open Access Date: 23 April 2018
Grantor: Université Laval
Collection:Thèses et mémoires

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