Étude Monte Carlo des effets de l’orientation des sources et de la présence de calcifications dans la curiethérapie de prostate à bas débit de dose

Authors: Collins Fekete, Charles-Antoine
Advisor: Beaulieu, Luc
Abstract: Prostatic brachytherapy is performed by inserting radioactive seeds in a tumoral zone. Because of time constraint, clinical planning considers those seeds as point sources in a water medium. This thesis presents the quantification of the impact of two perturbing effects on the dosimetry, evaluated through a Monte Carlo algorithm, in prostatic brachytherapy. Seeds orientation, actually neglected, may alter the clinical dosimetry. The impact of this effect is evaluated on a cohort (n=287) of patients. No effect is calculated on the prostate or the urethra but a difference of -2%, when compared to the clinical algorithm, is calculated on the OARs. Calcifications are actually neglected in the clinical planning. A cohort of patients (n=43) with visible calcifications is used to measure the effect of this approximation. MC calculations yield a difference of -13% on the CTV D90 and -16% on the urethra D10, when compared to the clinical algorithm.
Document Type: Mémoire de maîtrise
Issue Date: 2014
Open Access Date: 20 April 2018
Permalink: http://hdl.handle.net/20.500.11794/25577
Grantor: Université Laval
Collection:Thèses et mémoires

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