Étude Monte Carlo des effets de l’orientation des sources et de la présence de calcifications dans la curiethérapie de prostate à bas débit de dose
|Authors:||Collins Fekete, Charles-Antoine|
|Abstract:||Prostatic brachytherapy is performed by inserting radioactive seeds in a tumoral zone. Because of time constraint, clinical planning considers those seeds as point sources in a water medium. This thesis presents the quantification of the impact of two perturbing effects on the dosimetry, evaluated through a Monte Carlo algorithm, in prostatic brachytherapy. Seeds orientation, actually neglected, may alter the clinical dosimetry. The impact of this effect is evaluated on a cohort (n=287) of patients. No effect is calculated on the prostate or the urethra but a difference of -2%, when compared to the clinical algorithm, is calculated on the OARs. Calcifications are actually neglected in the clinical planning. A cohort of patients (n=43) with visible calcifications is used to measure the effect of this approximation. MC calculations yield a difference of -13% on the CTV D90 and -16% on the urethra D10, when compared to the clinical algorithm.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||20 April 2018|
|Collection:||Thèses et mémoires|
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