Étude de l’influence des neurones sensoriels dans deux mécanismes de l’inflammation neurogène : l’angiogenèse et la réépithélialisation en condition glyquée

Authors: Mottier, Lorène
Advisor: Berthod, François
Abstract: Neurogenic inflammation is an inflammatory process, characterized by the release of neuropeptides, particularly substance P and Calcitonin Gene-Related Peptide (CGRP), in sensory neurons. During this process, angiogenesis and reepithelialization following an injury are essential to reduce inflammation. Within certain diseases, such as diabetes, angiogenesis is diminished, and patients are often suffering of diabetic neuropathies and poor wound healing. To understand that process, two models were reconstructed using tissue engineering with a collagen and chitosan sponge: one model mimics a reconstructed endothelialized and innervated dermis, and the second one follows over time re-epithelialization in a glycated model using glyoxal. Based on our results, substance P seems to be a neuropeptide playing a major role in both mechanisms.
Document Type: Mémoire de maîtrise
Issue Date: 2014
Open Access Date: 20 April 2018
Permalink: http://hdl.handle.net/20.500.11794/25505
Grantor: Université Laval
Collection:Thèses et mémoires

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