L'infection herpétique un facteur environnemental impliqué dans la progression de l'arthrite rhumatoïde
|Advisor:||Gosselin, Jean; Brunet, Alexandre|
|Abstract:||For several years, the Epstein-Barr virus (EBV) is suspected to be involved in rheumatoid arthritis (RA) pathogenesis. Using a mouse model of arthritis, it was previously demonstrated that infection of arthritic mice with the herpes virus MHV-68, resulted in exacerbation of inflammation in joints of mice. Furthermore, this phenomenon was MHV-68 specific since no other herpes virus such as HSV-1 of mCMV was found to increase joint inflammation of arthritic mice. The presence of MHV-68 genome in synovial tissues of arthritic mice and subsequently in inflammatory monocytes also suggest the potential role of these cells in virus transport to the joint of arthritic mice. Together, these findings demonstrate the key role of inflammatory monocytes in exacerbation of inflammatory symptoms induced by MHV-68 in arthritic mice. The involvement of TLR2, TLR9 and EBV is also suggested in RA pathogenesis.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||20 April 2018|
|Collection:||Thèses et mémoires|
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