In vivo imaging of blood-brain barrier disruption in a multiple sclerosis animal model

Authors: Chamma, Émilie
Advisor: De Koninck, YvesCôté, Daniel
Abstract: Multiple sclerosis is an inflammatory disease of the central nervous system that affects many young adults worldwide. Despite research efforts, the cause of the disease remains unknown. In order to develop better therapies and ultimately find a cure, animal models are used to identify cellular biomarkers. Characterizing these models is essential in order to properly relate findings to the human disease and test possible medications. This thesis is the result of a three-year Master's project at Centre de recherche de l'Institut universitaire en santé mentale de Québec (CRIUSMQ) that aimed to study the blood-brain barrier as a possible biomarker of disease pathology in a multiple sclerosis animal model. Chapter 1 introduces the different themes addressed in this project. Chapters 2, 3 and 4 focus on the materials and methods chosen, while chapter 5 presents the results obtained. These findings are discussed in chapter 6.
Document Type: Mémoire de maîtrise
Issue Date: 2013
Open Access Date: 19 April 2018
Grantor: Université Laval
Collection:Thèses et mémoires

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