Développement de nouveaux dosimètres à scintillateurs plastiques pour des applications in vivo en radiothérapie et curiethérapie à haut débit de dose

Authors: Therriault-Proulx, François
Advisor: Beaulieu, LucBeddar, Sam
Abstract: The goal of this thesis is to develop new plastic scintillation dosimetry systems to enable the measurement of in vivo doses in real time and the verification of the treatment delivery accuracy for radiation therapy, especially for high dose rate brachytherapy. The necessity to account for the stem effect light produced in the optical guide by radiation was first shown. The detector built for this study was then used to verify its accuracy to measure dose in real time during the delivery of a typical prostate treatment plan in high dose rate brachytherapy. This measurement was performed inside a water phantom. Dose deposited at each dwell position, inside each catheter and for the entire treatment delivery was measured and compared to the treatment planning system. Another part of this research project was on the development of an approach to render possible measurement at multiple positions with the use of multiple scintillating elements and only a single collecting optical guide. Plastic scintillation detectors with 2 and 3 points of measurement were first developed and used under external beam high energy radiation therapy. The approach enabled the calculation of different signal contributions over the total optical signal; a study was then performed to evaluate the importance of the fluorescence component on the total stem effect under a variety of irradiation modalities and conditions. Finally, a 3-point detector was inserted inside a single catheter to perform dosimetry under Ir-192 high dose rate brachytherapy in a water phantom. Its accuracy to measure dose was demonstrated. An uncertainty budget was also calculated in order to evaluate the limitations of this detector for its clinical potential as a real-time in vivo dosimeter.
Document Type: Thèse de doctorat
Issue Date: 2012
Open Access Date: 19 April 2018
Permalink: http://hdl.handle.net/20.500.11794/23991
Grantor: Université Laval
Collection:Thèses et mémoires

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