Stimulation de l'immunité innée pulmonaire avec des nanoparticules du virus de la mosaïque de la papaye

Authors: Mathieu, Claudia
Advisor: Leclerc, Denis
Abstract: Stimulation of immune responses in the lungs is one of the most effective ways to prevent respiratory infections. We previously demonstrated that papaya mosaic virus (PapMV) nanoparticles can increase specific immune responses towards antigens and can induce systemic activation of the innate immunity. In this study, the accumulation of IL-6, TNF-α, KC, MIP-1α, MIP-1β, MIP-2, IL-9 and IP-10 followed by the recruitment of neutrophils, monocytes/macrophages and lymphocytes in the lungs of mice demonstrated the ability of PapMV nanoparticles to stimulate lung innate immunity. In addition, this stimulation was sufficient to protect mice against a lethal influenza virus challenge in the absence of specific antigens. These results suggest that PapMV nanoparticles efficiently stimulate mucosal innate immunity and therefore are promising candidates to establish a non-specific antimicrobial state at mucosal surfaces. Moreover, these data strengthen the potential of PapMV nanoparticles as a mucosal adjuvant.
Document Type: Mémoire de maîtrise
Issue Date: 2012
Open Access Date: 18 April 2018
Grantor: Université Laval
Collection:Thèses et mémoires

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