Modulation de l'activité des neutrophiles humains par la prostaglandine E₂ glycérylester

Authors: Jean, Stéphanie
Advisor: Flamand, Nicolas
Abstract: Even though the anti-inflammatory impact of cannabis and its less or more purified extracts are well characterised, the functions of the main endocannabinoids (2-arachidonoyl-glycerol and arachidonyl-ethanolamide) in the regulation of inflammation are still intriguing. In fact, endocannabinoids exert pro- and anti-inflammatory effects which are, in part, explained by their complex metabolism. For example, 2-arachidonoyl-glycerol and arachidonyl-ethanolamide can both be oxidized by the cyclooxygenase-2 enzyme into prostanglandin E2-glycerylester and –ethanolamide respectively, whose effects on neutrophils are still unknown. Since neutrophils functions are affected by prostaglandin E2, we wanted to test the impacts of prostanglandin E2-glycerolester and prostanglandin E2-ethanolamide on neutrophil functions. The present study shows that, unlike prostanglandin E2-ethanolamide, prostanglandin E2-glycerolester inhibits human neutrophils functions. This inhibition is caused by the activation of EP2 and EP4 receptors and the subsequent activation of cyclic AMP-dependant protein kinase.
Document Type: Mémoire de maîtrise
Issue Date: 2012
Open Access Date: 18 April 2018
Grantor: Université Laval
Collection:Thèses et mémoires

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