Le rôle de la régulation transcriptionnelle dans l'évolution des réseaux d'interaction protéine-protéine
|Abstract:||Evolution by gene duplication is considered one of the most important mechanisms of evolutionary innovation. What is less known and highly debated is the relative role of the divergence of transcriptional regulation and the divergence of protein coding sequence in the evolution of molecular networks. We developed a method aimed at evaluating the role of transcriptional regulation in the divergence of protein-protein interactions among duplicated genes in the budding yeast Saccharomyces cerevisiae. Our results demonstrate that our approach can be used effectively to test if divergence of protein-protein interaction profiles can be explained by the divergence of transcriptional regulation or the divergence of coding sequences. We found evidence supporting different scenarios, whereby expression regulation has a large effect, no effect or little effect on protein-protein interaction profiles of paralogous proteins. Our method can be brought to large scale and help elucidate the importance of gene transcriptional regulation in evolution of complex cellular networks.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||18 April 2018|
|Collection:||Thèses et mémoires|
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