Implications de la résistine et de la protéine stimulant l'acylation dans le développement de co-morbidités de l'obésité
|Advisor:||Cianflone, Katherine M.|
|Abstract:||Adipose tissue has been recently recognized to function as an endocrine organ in addition to its fat storage capacities. Adipose tissue secretes a number of factors named adipokines. Some of these hormones influence metabolism similarly to other well-known factors such as insulin and glucagon. This thesis is the result of studies done on two particular adipokines, acylation stimulating protein (ASP) and resistin, as well as their relationship with obesity and its co-morbidities. The aim of the first project was to understand the adaptations of hepatic metabolism in murine models with ASP-C5L2 pathway deficiencies, models that are also obesity resistant. This study demonstrated the absence of hepatic steatosis or lipoprotein overproduction in these mice in addition to showing signs of altered substrate use by the liver. The second study evaluated correlations between plasma resistin and several parameters related to the metabolic syndrome in a population of Chinese children and adolescents. This study demonstrated that resistin does not correlate with insulin resistance, but that circulating levels of resistin are increased in the presence of central obesity. Globally, this thesis shows, from both a clinical and basic science perspective, the physiological implications of the two adipokines studied – ASP and resistin – and clarifies their therapeutical potential.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||16 April 2018|
|Collection:||Thèses et mémoires|
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