Étude de l'implication de la E-sélectine et de son récepteur, le Death receptor 3, dans le processus métastatique
|Abstract:||E-selectin, a specific endothelial adhesion receptor, interacts with Death Receptor 3 (DR3) expressed by colon cancer cells. In this study, we investigated further the mechanisms by which the E-selectin-activated pathways downstream of DR3 confer a survival advantage to colon cancer cells. We found that DR3 exists under both transmembrane and secreted versions in HT29 cells. These Death Domain deleted isoforms hamper apoptosis. Additionally, we found that E-selectin could trigger the tyrosine phosphorylation Tyr285 of DR3 in a Src family member-dependent manner. We also obtained evidence indicating that E-selectin and TL1A induce the PI3K/Akt/NFκB p65 survival axis.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||16 April 2018|
|Collection:||Thèses et mémoires|
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