Étude des concentrations d'antioxydants plasmatiques après supplémentation en vitamines E et C au cours de la grossesse

Authors: Gagné, Amélie
Advisor: Julien, Pierre; Fraser, William Donald
Abstract: Preeclampsia (PE) is a syndrome characterized by hypertension and maternal proteinuria during pregnancy. Some studies have suggested that supplementation with vitamins (E and C) could decrease the incidence of PE. Women (n=100) from the International Trial of Antioxidants for the Prevention of PE study were collected at week 12-16 of gestation (prior to vitamins supplementation), then at weeks 24 and 32 of gestation. A second group of 15 preeclamptic women was also selected for this study. Vitamins were determined using high-performance liquid chromatography. The higher α-tocopherol and coenzyme Q10 concentrations during pregnancy in non-supplemented women, with or without PE, could represent a naturally response against oxidative stress in pregnant women. The lower ratio of γ-/α-tocopherol, observed for the first time in supplemented pregnant women, suggest an increase in plasma α-tocopherol due to dietary supplementation and/or a decrease in γ-tocopherol resulting from a competition for the intestinal absorption of tocopherols.
Document Type: Mémoire de maîtrise
Issue Date: 2009
Open Access Date: 16 April 2018
Permalink: http://hdl.handle.net/20.500.11794/20708
Grantor: Université Laval
Collection:Thèses et mémoires

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