Les mécanismes de dépense énergétique associés avec l'ASP et son récepteur C5L2
|Advisor:||Cianflone, Katherine M.|
|Abstract:||Obesity is a well established problem in North America and studying the mechanisms of fat storage may be key in understanding and treating this problem. Acylation Stimulating Protein (ASP) is an adipose tissue derived hormone that acts through its receptor, C5L2, to stimulate triglyceride (TG) synthesis and glucose transport. C3 is the precursor for ASP; therefore, C3 knockout (KO) mice are ASP-deficient. These mice display hyperphagia yet normal body weight due to increased energy expenditure. Calorimetric chamber studies demonstrated that C3KO have increased oxygen consumption and lowered respiratory quotient, indicating that deficiency of ASP alters substrate preference for energy metabolism in C3KO mice. It still remains to be determined whether the alterations in skeletal muscle energy metabolism are a direct or indirect consequence of ASP deficiency, but in vivo data suggest targeting ASP may provide insights toward treatment of obesity.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||13 April 2018|
|Collection:||Thèses et mémoires|
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