La transplantation de myoblastes protège le muscle MDX du dommage induit par les contractions excentriques

Authors: Tagmouti, Saloua
Advisor: Tremblay, Jacques-P.
Abstract: Duchenne muscular dystrophy is a hereditary dystrophy that results from a mutation of the dystrophin gene, which induces the weakness of muscles. Although several studies have already shown that the transplantation of normal myoblasts permit to restore the expression of dystrophin, no physiological study was made to verify whether myoblast transplantation is able to improve the muscle contractile properties. In this study, I have studied the effects of normal myoblast transplantation on the contractile properties of muscles of mdx mice, a model of Duchenne Muscular Dystrophy. My studies have shown that the transplantation of normal myoblasts protects mdx muscle from damage induced by eccentric contractions, and that this effect can not be explained only by the expression of dystrophin. Indeed, the comparison of mdx muscles transplanted with mdx myoblasts with non-transplanted muscles indicated that the transplanted muscles are more resistant to eccentric contractions than the non-transplanted ones.
Document Type: Mémoire de maîtrise
Issue Date: 2007
Open Access Date: 13 April 2018
Grantor: Université Laval
Collection:Thèses et mémoires

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