Impact des interactions gène-environnement sur l'expression de deux gènes reliés à la croissance chez l'omble de fontaine, Salvelinus fontinalis
|Advisor:||Bernatchez, Louis; Blier, Pierre|
|Abstract:||Genotype-by-environment interaction is well established as a factor responsible for the phenotypic variation that occurs between different environments. However, genetic architecture behind this GxE interaction is not well understood. In this context, the aim of this study was to determine the impact of interactions between environment, sex and genetic value on the expression level of two keys genes associated with the GH/IGF system (growth hormone receptor, GHR and insulin-like growth factor, IGF-1), and their influence on growth in the brook charr, Salvelinus fontinalis. The results show that i) growth was higher for fish reared in freshwater as compared to those reared in saltwater and that males had a higher growth rate than females, ii) expression level of genes associated with the GH/IGF axis was higher in saltwater, iii) expression level of GHR and IGF-1 of males was higher than that of females, iv) there is GxE interaction for individual gene expression. This work represents a marked advance towards mapping environmentally and sexually induced variance of gene activity and to understand the resulting phenotypes.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||13 April 2018|
|Collection:||Thèses et mémoires|
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