Caractérisation moléculaire de la protéine antibiotique P1 du phage AP205

Authors: Paquet-Bouchard, Carine
Advisor: Lévesque, Roger C.
Abstract: The constant increase of infectious diseases and bacterial resistance to antibiotics are major problems of public health. Thus, development of a new class of antimicrobial agents is very urgent. We have decided to explore bacteriophages to learn more about the way they kill bacteria. Therefore, until now, the knowledge about this bactericidal activity is limited. We have characterized the inhibition mechanism of P1 lysis protein from phage AP205 using in vitro and in vivo approaches. The host of this phage is Acinetobacter. The P1 lysis protein targets an essential element for the bacterial survival, the bacterial cell wall. Actually, we hope that knowledge about this protein will contribute to the development of a new class of antibiotics.
Document Type: Mémoire de maîtrise
Issue Date: 2006
Open Access Date: 12 April 2018
Grantor: Université Laval
Collection:Thèses et mémoires

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