Effets d'un antioxydant, le tempol, sur les actions métaboliques et vasculaires de l'insuline chez le rat insulino-résistant avec un surplus de poids. Effets de l'insuline sur le transport du glucose dans le muscle squelettique, la réactivité vasculaire, l'expression des protéines eNOS, le stress oxydatif et les effets hémodynamiques régionaux

Authors: Badeau, Mylène
Advisor: Bachelard, Hélène
Abstract: In the Western hemisphere, the incidence of type 2 diabetes and obesity have been growing at an alarming rate. Their consequences on public health, economic situation and population’s future are major. My research project at the Master degree was designed to characterize metabolic and vascular dysfunctions elicited in a rat model fed a high fat and high sucrose diet, and to examine in this animal model the effect of a chronic treatment with the antioxidant, tempol. Our results indicate that treatment with tempol significantly improves insulin sensitivity measured during a euglycemic hyperinsulinemic clamp, reduces weight gain, increases endothelium eNOS protein expression (confocal microscopy) and reduces nitrotyrosine formation in aortas. An improvement in insulin-mediated glucose transport activity in skeletal muscles and in vascular reactivity were also noted. These results not only suggest the presence of a close link between diet, cardiovascular diseases, oxidative stress and eNOS, but also indicate the ability of treatment with tempol to significantly improve insulin sensitivity and endothelial functions in this rat model.
Document Type: Mémoire de maîtrise
Issue Date: 2006
Open Access Date: 12 April 2018
Permalink: http://hdl.handle.net/20.500.11794/18703
Grantor: Université Laval
Collection:Thèses et mémoires

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