Caractérisation de l'association entre les effets vasculaires et métaboliques de l'insuline chez des rats insulino-résistants et ayant un surplus de poids
|Abstract:||Insulin resistance (IR) plays a role in the development of obesity, type 2 diabetes and cardiovascular diseases. This study was initiated to characterize vascular and metabolic dysregulations in a rat model with IR fed a high fat high sucrose diet (HFHS). Insulin sensitivity, endothelial function and eNOS (endothelial nitric oxide synthase) gene expression were studied. The results indiquate that the HFHS diet induce an alteration of the vasodilation associated with a reduction of eNOS protein expression in skeletal muscles and thoracic aorta. Also, a reduction of NO (nitric oxide) bioavailability was observed, linked with an augmentation of nitrotyrosine and endothelin. This study show that eNOS is crucial in the development of metabolic and vascular diseases and that there is a geneenvironnement interaction in NO regulation.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||12 April 2018|
|Collection:||Thèses et mémoires|
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