Méthode d'analyse de liaison génétique pour des familles dans lesquelles il y a de l'hétérogénéité non-allélique intra-familiale
|Advisor:||Rivest, Louis-Paul; Mérette, Chantal|
|Abstract:||This study presents a linkage analysis method for cases of recombination heterogeneity when it is located in bilineal pedigrees. We propose a modification of the single-locus analysis by Smith's admixture model - which is concerned with inter-familial heterogeneity - so it becomes more appropriate for cases of intra-familial heterogeneity. Our approach first consists in decomposing large pedigrees into nuclear pedigrees so that the intra-familial heterogeneity of the large pedigrees is transformed into inter-familial heterogeneity between the nuclear pedigrees. Then, the nuclear pedigrees are considered both with a single-locus analysis and Smith's admixture model. The power of the proposed method is compared to the power of other methods, including the power of the specific case where there is intra-familialheterogeneity in large pedigrees. We also verify if the decomposition of the pedigrees results in a bigger proportion of type I errors.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||11 April 2018|
|Collection:||Thèses et mémoires|
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