Modulation of intrinsic and synaptic excitability during sleep oscillations and electrographic seizures

Authors: Boucetta, Soufiane
Advisor: Timofeev, Igor
Abstract: The present memoir provides new evidences showing the modulation of intrinsic and synaptic excitability of cortical neurons, and the consequence of this modulation on neuronal activity during both slow sleep oscillations and electrographic seizures in vivo in anaesthetized animals. We performed simultaneous recordings of cortical neurons with local field potentials in suprasylvian gyrus within parietal associative cortex (area 5, 7 and 21). We suggest that the fluctuation of extacellular calcium concentration during slow sleep oscillations, modulates both intrinsic and synaptic excitability cortical neurons, thus by consequence modulates the input-output relationship of these neurons. The occurrence during slow-wave sleep of cortically generated Lennox-Gastaut type of seizures admits us to study the spatio-temporal properties of paroxysmal fast runs associated with this type of seizures. We suggest that fast runs appeared as quasi-independent oscillations even in neighbouring cortical locations suggesting their focal origin.
Document Type: Mémoire de maîtrise
Issue Date: 2005
Open Access Date: 11 April 2018
Grantor: Université Laval
Collection:Thèses et mémoires

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