Caractérisation de la réactivité vasculaire et des actions hémodynamiques de l'insuline chez le rat spontanément hypertendu nourri avec une alimentation sucrosée
|Abstract:||Several clinical studies carried out in humans have demonstrated an association between hypertension, insulin resistance and endothelial dysfunction. The same association has also been shown in several animal models, including the spontaneously hypertensive rat (SHR), and the high sucrose-fed rat. Consequently, we undertook a series of experiments to characterize the effects of hypertension combined with those of a high sucrose diet on insulin sensitivity, insulin’s haemodynamic and metabolic actions, endothelial function and in vivo and in vitro vascular reactivity. Our results clearly indicate significant alterations in aortic vascular reactivity, as well as in insulin haemodynamic responses measured during a euglycemic/hyperinsulinemic clamp in the SHR rat. These effects were independent of diet. We also noted a decrease in skeletal muscle glucose transport activity and in eNOS protein expression.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||11 April 2018|
|Collection:||Thèses et mémoires|
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