Conception et validation d'un bioréacteur spécifique à la régénération du tissu artériel sous contraintes mécaniques

Authors: Bilodeau, Katia
Advisor: Mantovani, D.
Abstract: Tissue engineering provides a new approach for overcoming the current problem of organ shortage and biomaterial failure. Three-dimensional tissues, such as arteries, are much more difficult to regenerate than bi-dimensional ones. In this context, a specific bioreactor is required in order to reproduce and maintain the appropriate environment required for 3-D tissue regeneration. During this project, a perfusion bioreactor specific for arterial tissue was designed to stimulate growth and study the effects of mechanical factors such as axial stress, axial strain, internal pressure, flow and shear stress, on final construct properties. The design was realized following a step-by-step methodology: identification of the needs, listing of the specifications, computer assisted modeling and design, and prototype realisation and validation. This bioreactor will be used by the laboratory for the development of an arterial substitute with similar properties and structure of a native artery.
Document Type: Mémoire de maîtrise
Issue Date: 2004
Open Access Date: 11 April 2018
Grantor: Université Laval
Collection:Thèses et mémoires

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