Interactions neurones-glie : l'ACh et les glies lors de la transition du sommeil vers l'éveil in vivo
|Abstract:||This study summarizes the history of the glial discovery, details their morphology and their physiology and aims at understanding complex interactions between cortical neurons, glia and blood supply during the transition from slow wave sleep to wakefulness in vivo in both anesthetized and naturally sleeping animals. We performed simultaneous intracellular recordings of cortical neurons and glia, together with measurements of cerebral blood flow, extracellular K+ concentrations and local field potentials under anesthesia, during elicited cortical activation with electric stimulation of cholinergic nuclei or under naturally wakefulness of the animal. We suggest that the outcome of the glial behavior depends on the glutamatergic/GABAergic influence of neighboring neurons, on the modulation of the interglial communication pathways, and/or on the ionic traffic across blood vessels.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||11 April 2018|
|Collection:||Thèses et mémoires|
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