Contribution de la protéine de transfert des esters de cholestérol à l'hétérogénéité des particules LDL dans l'hypercholestérolémie familiale hétérozygote
|Advisor:||Couture, Patrick; Lamarche, Benoît|
|Abstract:||The main objective of this study was to examine the relationship between CETP and LDL particle heterogeneity in heterozygous familial hypercholesterolemia. The results of this study suggest that the LDL peak particle diameter was smaller in familial hypercholesterolemia than in controls. Furthermore, the results suggest that several factors are implicated in the LDL particle heterogeneity and that some of them are associated with familial hypercholesterolemia, such as the plasma CETP concentration. This study suggest that increased plasma CETP concentration could lead to significant LDL particle remodeling in familial hypercholesterolemia and could contribute to the pathogenesis of atherosclerosis in these patients.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||11 April 2018|
|Collection:||Thèses et mémoires|
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