Développement accéléré de nouveaux inhibiteurs contre les protéines de division cellulaire FtsZ et FtsA de Pseudomonas aeruginosa

Authors: Paradis-Bleau, Catherine
Advisor: Lévesque, Roger C.
Abstract: The impact of bacterial infections and emergence of antibiotic resistance led to a serious need to develop new class of antibacterials. The acute resistance of the opportunistic pathogen Pseudomonas aeruginosa lowers the treatment efficiency of infected cystic fibrosis patients and immuno-compromised individuals. In the perspective of finding new antimicrobial agents, we are using the bacterial cell division machinery of as a new target. Thus, P. aeruginosa cell division proteins FtsZ and FtsA have been used to identify inhibitory peptides with the phage-display technique. We identified FtsZ and FtsA tight binding peptides and we characterized three inhibitory peptides of FtsZ GTPase activity. Peptidomimetism will allow the development of new antimicrobial agents with these leader peptides.
Document Type: Mémoire de maîtrise
Issue Date: 2003
Open Access Date: 11 April 2018
Permalink: http://hdl.handle.net/20.500.11794/17860
Grantor: Université Laval
Collection:Thèses et mémoires

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