NR4A orphan nuclear receptors in glucose homeostasis : a minireview

Authors: Close, Anne-Françoise; Rouillard, ClaudeButeau, Jean
Other Title(s): Les récepteurs nucléaires orphelins NR4A et l’homéostasie du glucose : une minirevue
Abstract: Type 2 diabetes mellitus is a disorder characterized by insulin resistance and a relative deficit in insulin secretion, both of which result in elevated blood glucose. Understanding the molecular mechanisms underlying the pathophysiology of diabetes could lead to the development of new therapeutic approaches. An ever-growing body of evidence suggests that members of the NR4A family of nuclear receptors could play a pivotal role in glucose homeostasis. This review aims to present and discuss advances so far in the evaluation of the potential role of NR4A in the regulation of glucose homeostasis and the development of type 2 diabetes.
Document Type: Article de recherche
Issue Date: 26 September 2013
Open Access Date: Restricted access
Document version: VoR
This document was published in: Diabetes and metabolism, Vol. 39 (6), 478–484 (2013)
Elsevier Masson
Alternative version: 10.1016/j.diabet.2013.07.005
Collection:Articles publiés dans des revues avec comité de lecture

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