Extracellular signal-regulated kinases (ERK) and protein kinase C (PKC) activities are involved in the modulation of Nur77 and Nor-1 expression by dopaminergic drugs

DC FieldValueLanguage
dc.contributor.authorBourhis, Emmanuelle-
dc.contributor.authorMaheux, Jérôme-
dc.contributor.authorRouillard, Claude-
dc.contributor.authorLévesque, Daniel-
dc.date.accessioned2018-02-09T15:08:59Z-
dc.date.available9999-12-31-
dc.date.issued2008-07-04-
dc.identifier.issn0022-3042fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/16942-
dc.description.abstractThe dopamine system is the main target of antipsychotic and psychostimulant drugs. These drugs induce intracellular events that culminate in the transcription of immediate early genes, such as c-fos. Another class of transcription factors, namely, the nuclear receptor subgroup called Nurs (Nur77, Nurr1 and Nor-1), has recently been associated with behavioral and biochemical effects mediated by dopamine. However, the signaling cascade leading to modulation of Nur mRNA levels in the brain has never been investigated. In the present study, we explore in vivo using specific kinase inhibitors the role of mitogen-associated and extracellular signal-regulated kinases (MEK) and protein kinase C (PKC) in the modulation of Nur expression induced by dopamine receptor drugs. Modulation of Nur77 expression by a dopamine D2 receptor antagonist is associated with MEK and PKC activities, whereas only the PKC activity participates in the modulation of Nor-1 expression. Both MEK and PKC activities also participate in the modulation of Nur77 mRNA levels induced by dopamine receptor agonists, whereas a selective MEK activity is associated with the modulation of Nor-1 mRNA levels. Interestingly, modulation of dopamine drug-induced locomotor activities by kinase inhibitors is in accordance with the effects on Nur77, but not Nor-1, expression. Taken together, the results indicate that signaling events leading to modulation of Nur77 and Nor-1 expression following dopamine receptor interacting drugs are distinct. Considering that orphan nuclear receptors of the Nur subgroup display an important ligand-independent constitutive activity, characterization of the signaling cascades involved in the regulation of their expression represents an important step for understanding their role in dopamine system physiology and pathophysiology.fr
dc.languageengfr
dc.publisherRaven Pressfr
dc.subjectAntipsychotic drugsfr
dc.subjectCatalepsyfr
dc.subjectDopamine D1 receptorfr
dc.subjectDopamine D2 receptorfr
dc.subjectGene transcriptionfr
dc.subjectIn situ hybridizationfr
dc.subjectLocomotor activityfr
dc.subjectMitogen-associated protein kinasesfr
dc.subjectNGFI-Bfr
dc.subjectNR4Afr
dc.subjectNurr1fr
dc.subjectPsychostimulantsfr
dc.subjectStriatumfr
dc.titleExtracellular signal-regulated kinases (ERK) and protein kinase C (PKC) activities are involved in the modulation of Nur77 and Nor-1 expression by dopaminergic drugsfr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationJournal of Neurochemistry, Vol. 106 (2), 875–888 (2008)fr
dc.identifier.doi10.1111/j.1471-4159.2008.05455.xfr
dc.identifier.pubmed18466322fr
dc.subject.rvmFacteurs de transcriptionfr
dc.subject.rvmProtéine kinase Cfr
dc.subject.rvmMAP kinasesfr
dc.subject.rvmSystèmes dopaminergiquesfr
dc.subject.rvmDopamine -- Récepteursfr
dc.subject.rvmNeuroleptiquesfr
dc.subject.rvmRécepteurs nucléaires (Biochimie)fr
rioxxterms.versionVersion of Recordfr
rioxxterms.version_of_recordhttps://doi.org/10.1111/j.1471-4159.2008.05455.xfr
rioxxterms.project.funder_nameCanadian Institutes of Health Researchfr
rioxxterms.project.funder_nameParkinson’s Disease Foundationfr
bul.rights.periodeEmbargoInfinifr
dc.audience.peerreviewOuifr
Collection:Articles publiés dans des revues avec comité de lecture

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