Nur77 and retinoid X receptors : critical factors in dopamine-related neuroadaptation

DC FieldValueLanguage
dc.contributor.authorLévesque, Daniel-
dc.contributor.authorRouillard, Claude-
dc.date.accessioned2018-02-09T14:56:03Z-
dc.date.available2018-02-09T14:56:03Z-
dc.date.issued2006-11-28-
dc.identifier.issn0378-5912fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/16941-
dc.description.abstractDopaminergic systems in the brain adapt in response to various stimuli from the internal and external world, but the mechanisms underlying this process are incompletely understood. Here, we review recent evidence that certain types of transcription factor of the nuclear receptor family, specifically Nur77 and retinoid X receptors, have important roles in adaptation and homeostatic regulation of dopaminergic systems. These findings call for a reassessment of our fundamental understanding of the molecular and cellular basis of dopamine-mediated transmission. Given that diseases such as Parkinson's disease and schizophrenia are thought to involve adaptation of dopamine signalling, these findings might provide new insight into these pathologies and offer new avenues for drug development.fr
dc.languageengfr
dc.publisherElsevier Science Publishersfr
dc.titleNur77 and retinoid X receptors : critical factors in dopamine-related neuroadaptationfr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationTrends in Neurosciences, Vol. 30 (1), 22-30 (2007)fr
dc.identifier.doi10.1016/j.tins.2006.11.006fr
dc.identifier.pubmedPMC5333988fr
dc.subject.rvmDopaminefr
dc.subject.rvmSystèmes dopaminergiquesfr
dc.subject.rvmFacteurs de transcriptionfr
dc.subject.rvmRétinoïdesfr
rioxxterms.versionAccepted Manuscriptfr
rioxxterms.version_of_recordhttps://doi.org/10.1016/j.tins.2006.11.006fr
rioxxterms.project.funder_nameCanadian Institutes of Health Researchfr
rioxxterms.project.funder_nameParkinson Society Canadafr
rioxxterms.project.funder_nameParkinson’s Disease Foundation of United Statedfr
bul.rights.periodeEmbargo12 moisfr
dc.audience.peerreviewOuifr
Collection:Articles publiés dans des revues avec comité de lecture

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