Nur77 and retinoid X receptors : critical factors in dopamine-related neuroadaptation

Auteur(s): Lévesque, DanielRouillard, Claude
Résumé: Dopaminergic systems in the brain adapt in response to various stimuli from the internal and external world, but the mechanisms underlying this process are incompletely understood. Here, we review recent evidence that certain types of transcription factor of the nuclear receptor family, specifically Nur77 and retinoid X receptors, have important roles in adaptation and homeostatic regulation of dopaminergic systems. These findings call for a reassessment of our fundamental understanding of the molecular and cellular basis of dopamine-mediated transmission. Given that diseases such as Parkinson's disease and schizophrenia are thought to involve adaptation of dopamine signalling, these findings might provide new insight into these pathologies and offer new avenues for drug development.
Type de document: Article de recherche
Date de publication: 28 novembre 2006
Date de la mise en libre accès: 9 février 2018
Version du document: AM
Lien permanent: http://hdl.handle.net/20.500.11794/16941
Ce document a été publié dans: Trends in Neurosciences, Vol. 30 (1), 22-30 (2007)
https://doi.org/10.1016/j.tins.2006.11.006
Elsevier Science Publishers
Autre version disponible: 10.1016/j.tins.2006.11.006
PMC5333988
Collection :Articles publiés dans des revues avec comité de lecture

Fichier(s) :
Description TailleFormat 
nihms868.pdf1.18 MBAdobe PDFMiniature
Télécharger
Tous les documents dans CorpusUL sont protégés par la Loi sur le droit d'auteur du Canada.