Nur77 and retinoid X receptors : critical factors in dopamine-related neuroadaptation

Authors: Lévesque, DanielRouillard, Claude
Abstract: Dopaminergic systems in the brain adapt in response to various stimuli from the internal and external world, but the mechanisms underlying this process are incompletely understood. Here, we review recent evidence that certain types of transcription factor of the nuclear receptor family, specifically Nur77 and retinoid X receptors, have important roles in adaptation and homeostatic regulation of dopaminergic systems. These findings call for a reassessment of our fundamental understanding of the molecular and cellular basis of dopamine-mediated transmission. Given that diseases such as Parkinson's disease and schizophrenia are thought to involve adaptation of dopamine signalling, these findings might provide new insight into these pathologies and offer new avenues for drug development.
Document Type: Article de recherche
Issue Date: 28 November 2006
Open Access Date: 9 February 2018
Document version: AM
This document was published in: Trends in Neurosciences, Vol. 30 (1), 22-30 (2007)
Elsevier Science Publishers
Alternative version: 10.1016/j.tins.2006.11.006
Collection:Articles publiés dans des revues avec comité de lecture

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