Modulating the activity of membrane-active peptides through Zn(II) complexation

Authors: Paquet-Côté, Pierre-Alexandre; Tuck, Kellie L.; Paradis, Jean-Philippe; Graham, Bimbil; Voyer, Normand
Abstract: Seeking to increase the selectivity of antimicrobial peptides for prokaryotic cells, we incorporated a bis-dipicolyl amine (bis-DPA) ligand at the N-terminus of de novo designed model peptides. The Zn2·bisDPA complex increases the interaction of peptides with anionic model membranes, while decreasing interactions with zwitterionic model membranes. Further, it improves the peptides’ antimicrobial activity and decreases their hemolytic activity without substantial changes to their secondary structure. Therefore, incorporating a Zn2·bisDPA complex is a useful strategy to enhance the selectivity of antimicrobial peptides.
Document Type: Article de recherche
Issue Date: 13 December 2017
Open Access Date: 13 December 2019
Document version: AM
This document was published in: Tetrahedron letters, Vol. 58 (50), 4672-4676 (2017)
Pergamon Press
Alternative version: 10.1016/j.tetlet.2017.10.066
Collection:Articles publiés dans des revues avec comité de lecture

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