Tissue-Engineered Ligament

Authors: Germain, LucieGoulet, FrancineCaron, CharlotteRancourt, DenisAuger, François A.Normand, A.
Abstract: Tissue bioengineering has attracted considerable interest in the biological and medical fields, notably in orthopaedics. In United States alone at least 90 000 patients per year undergo ligament reconstruction [39]. As is often reported, in contrast with the medial collateral ligament, anterior cruciate ligament (ACL) regeneration is hampered in vivo [32, 42, 48]. In the young and active population reconstruction is often the best therapeutic option when indicated. Many clinical studies have attempted to develop new therapeutic alternatives such as allografts [4, 5] and synthetic prosthesis using carbon fiber, knitted Dacron and braided polypropylene (Ligament Augmentation Device) [13]. Patellar tendon and tensor fascia have frequently been used to replace torn ACL [5]. The success of the reconstruction depends on multiple factors such as the type of tissue used for the reconstruction, surgical technique, fixation of the graft; and revascularization of the transplanted tissues, progressively ensheathed in a vascular synovial envelope [5]. The tendon should finally acquire some ligament properties; and the word “ligamentization” was given by Amiel et al. [2] to describe this physiological phenomenon in vivo postgrafting.
Document Type: Chapitre d'ouvrage
Issue Date: 1 January 1997
Open Access Date: Restricted access
Document version: VoR
Permalink: http://hdl.handle.net/20.500.11794/16837
This document was published in: Ligaments and Ligamentoplasties
Alternative version: 10.1007/978-3-642-60428-7_18
Collection:Chapitres de livre

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