Human post-natal stem cells in organs produced by tissue engineering for clinical applications

Authors: Germain, LucieLarouche, DanielleAuger, François A.Fradette, Julie
Abstract: This chapter will focus on the clinical applications of post-natal stem cells. Massive tissue loss frequently requires grafting for proper healing. Considering that there is a shortage of organ donors, the expansion of cells in vitro and the reconstruction of tissues or organs constitute a very valuable alternative solution. The first clinical application of such tissues has been the autologous culture of epidermal cells for the treatment of burn patients, and will be presented herein. Since the cutaneous epithelium forms squames that are lost, it is continuously renewed every 28 days and its long-term regeneration depends on stem cells. The importance of preserving stem cells during in vitro expansion and after grafting will thus be discussed. Clinical applications of cultured cells from other tissues, such as limbal stem cells for corneal epithelium (surface of the eye) replacement, will also be reviewed. Finally, the development of new promising technologies and methods taking advantage of other sources of stem cells that could be isolated after birth from tissues such as adipose depots will also be presented.
Document Type: Chapitre d'ouvrage
Issue Date: 1 January 2008
Open Access Date: 31 January 2018
Document version: AM
This document was published in: Progress in stem cell applications
Nova Biomedical Books
Collection:Chapitres de livre

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