Mesenchymal cell culture : blood vessels

Authors: Germain, LucieRémy-Zolghadri, MurielleAuger, François A.
Edited by: Atala, Anthony
Lanza, Robert P.
Abstract: The replacement of small diameter vascular prostheses by nonautologous veins is the subject of intensive research. Attempts to produce synthetic, hybrid artificial or biological conduits are numerous and dependent on progress in technology and comprehension of the mechanisms implicated in their reconsrruction. The production of a completely biological vascular prosthesis is described in this chapter. Exclusively composed of human cells embedded in their own extracellular matrix, this graft could be produced autologously and offers advantages related to its biological composition. The steps to produce such a living structure are detailed, and some important areas, such as the purity and the phenotype of cells, and the application of mechanical strain to the construct, are pointed out as essential factors for the success of our tissue engineered blood vessel (TEBV). The main characteristics obtained with this prosthesis are presented, as well as directions future research could take to improve this human living prosthesis.
Document Type: Chapitre d'ouvrage
Issue Date: 31 January 2018
Open Access Date: Restricted access
Document version: VoR
This document was published in: Methods of tissue engineering
Academic Press
Collection:Chapitres de livre

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