Recent optimization of a tissue engineered blood vessel : the LOEX experience

DC FieldValueLanguage
dc.contributor.authorAuger, François A.-
dc.contributor.authorLaflamme, Karina-
dc.contributor.authorGrenier, Guillaume-
dc.contributor.authorRémy-Zolghadri, Murielle-
dc.contributor.authorGermain, Lucie-
dc.description.abstractCreating a blood vessel by tissue engineering is one of the most demanding goals in tissue engineering. Our laboratory developed, using the self-assembly approach, the first completely biological tissue engineered blood vessel (TEBV) constituted of living human cells in the absence of any synthetic or exogenous material. The phenotypic and functional variations of smooth muscle cell (SMC) are of paramount importance in TEBV reconstruction. Thus, the phenotype and extracellular matrix (ECM) production of SMC were studied along the whole sequence of TEBV production. The functional and mechanical properties can be greatly enhanced by active cell orientation in the ECM. Accordingly, the method of preparing living tissue engineered sheets was modified to obtain an optimal alignment of SMC before rolling them into a tubular form. These results have allowed us to create a better
dc.publisherExcerpta Medica Foundationfr
dc.subjectBlood vesselfr
dc.subjectRegenerative medicinefr
dc.subjectSmooth muscle cellsfr
dc.titleRecent optimization of a tissue engineered blood vessel : the LOEX experiencefr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationInternational Congress Series, Vol. 1262, 126-128 (2004)fr
dc.subject.rvmGénie tissulairefr
dc.subject.rvmVaisseaux sanguins -- Cultures et milieux de culturefr
dc.subject.rvmMédecine régénératricefr
dc.subject.rvmCellules musculaires lissesfr
dc.subject.rvmSubstance fondamentale (Histologie)fr
rioxxterms.versionVersion of Recordfr
rioxxterms.project.funder_nameCanadian Institutes of Health Researchfr
rioxxterms.project.funder_nameFonds de Recherche du Québec - Santéfr
rioxxterms.project.funder_nameHeart and Stroke Foundation of Canadafr
rioxxterms.project.funder_nameFondation de l'Hôpital du Saint-Sacrementfr
Collection:Autres articles publiés

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