Tissue-engineered skin substitutes: from in vitro constructs to in vivo applications

Authors: Auger, François A.Berthod, FrançoisMoulin, VéroniquePouliot, RoxaneGermain, Lucie
Abstract: The field of skin tissue engineering is a paradigm for the various efforts towards the reconstruction of other tissues and organ substitutes. As skin replacement, this biotechnological approach has evolved from simple cultured autologous epidermal sheets to more complex bilayered cutaneous substitutes. The various types of such substitutes are herein presented with their intended use. However, two integrative characteristics are analysed more specifically because of their critical role: neovascularization and re-innervation. Furthermore, the in vitro use of these various skin substitutes has shed light on various physiological and pathological phenomena. Thus, not only the in vivo application of these skin substitutes as grafts, but also their in vitro value as skin models, are presented.
Document Type: Article de recherche
Issue Date: 1 June 2004
Open Access Date: Restricted access
Document version: VoR
Permalink: http://hdl.handle.net/20.500.11794/16647
This document was published in: Biotechnology and applied biochemistry, Vol. 39 (Pt 3), 263-265 (2004)
Alternative version: 10.1042/BA20030229
Collection:Articles publiés dans des revues avec comité de lecture

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