Morphological changes of human skin cells exposed to a DC electric field in vitro using a new exposure system

Authors: Méthot, StéphaneMoulin, VéroniqueRancourt, Denis; Bourdages, Michel; Goulet, Daniel; Plante, MichelAuger, François A.Germain, Lucie
Abstract: The human skin contains a physiological battery that could be implicated in the healing process, by creating an endogenous electric field. Skin cells undergo morphological changes in response to an external DC electric field (EF). We found that fibroblasts reorient their cell bodies in a manner perpendicular to the EF direction, for normal and above physiological intensities. Actin and tubulin filaments (cytoskeleton proteins) follow the same pattern of reorientation. Keratinocytes tend to elongate in the same direction, although to a lesser extent. The study of the response of human skin cells to an external EF is a first step toward a better understanding of the mechanisms involved in wound healing and eventually toward the improvement of wound repair.
Document Type: Article de recherche
Issue Date: 1 August 2001
Open Access Date: Restricted access
Document version: VoR
This document was published in: The Canadian journal of chemical engineering, Vol. 79 (4), 668–677 (2001)
John Wiley & Sons
Alternative version: 10.1002/cjce.5450790428
Collection:Articles publiés dans des revues avec comité de lecture

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