Allogeneic-syngeneic cultured epithelia

DC FieldValueLanguage
dc.contributor.authorRouabhia, Mahmoud-
dc.contributor.authorGermain, Lucie-
dc.contributor.authorBergeron, Julie-
dc.contributor.authorAuger, François A.-
dc.description.abstractOrgan transplantation has progressed rapidly during the last decades. Furthermore, tissue engineering has and will continue to enlarge the scope of organ grafting. Thus, severe skin wounds, as observed in large burn trauma patients, can now be permanently treated with cultured autologous epithelial sheets. However, the time required for autologous cell growth is a major limitation. We propose to alleviate this pitfall through a novel chimeric (allogeneic-syngeneic) epithelial cell culture technique. These chimeric epidermal grafts implanted in an animal model have been shown to allow the reappearance of a histologically normal epidermal coverage similar to simultaneously performed isografts. The regenerated epidermis contained only syngeneic keratinocytes. Thus, allogeneic cells were eliminated passively. This new culture technology could find multiple applications, notably in various skin disease
dc.publisherWilliams & Wilkins
dc.titleAllogeneic-syngeneic cultured epitheliafr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationTransplantation, Vol. 59 (9), 1229–1235 (1995)fr
dc.subject.rvmCellules -- Culture -- Techniquefr
dc.subject.rvmCellules épithélialesfr
dc.subject.rvmPeau -- Greffefr
rioxxterms.versionVersion of Recordfr
Collection:Articles publiés dans des revues avec comité de lecture

Files in this item:
Description SizeFormat 
3.8 MBAdobe PDF    Request a copy
All documents in CorpusUL are protected by Copyright Act of Canada.