Allogeneic-syngeneic cultured epithelia

Auteur(s): Rouabhia, MahmoudGermain, LucieBergeron, JulieAuger, François A.
Résumé: Organ transplantation has progressed rapidly during the last decades. Furthermore, tissue engineering has and will continue to enlarge the scope of organ grafting. Thus, severe skin wounds, as observed in large burn trauma patients, can now be permanently treated with cultured autologous epithelial sheets. However, the time required for autologous cell growth is a major limitation. We propose to alleviate this pitfall through a novel chimeric (allogeneic-syngeneic) epithelial cell culture technique. These chimeric epidermal grafts implanted in an animal model have been shown to allow the reappearance of a histologically normal epidermal coverage similar to simultaneously performed isografts. The regenerated epidermis contained only syngeneic keratinocytes. Thus, allogeneic cells were eliminated passively. This new culture technology could find multiple applications, notably in various skin disease therapies.
Type de document: Article de recherche
Date de publication: 15 mai 1995
Date de la mise en libre accès: Accès restreint
Version du document: VoR
Lien permanent: http://hdl.handle.net/20.500.11794/16442
Ce document a été publié dans: Transplantation, Vol. 59 (9), 1229–1235 (1995)
https://doi.org/10.1097/00007890-199505000-00001
Williams & Wilkins Co.
Autre version disponible: 10.1097/00007890-199505000-00001
7762053
Collection :Articles publiés dans des revues avec comité de lecture

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