Association of prenatal exposure to gestational diabetes with offspring body composition and regional body fat distribution

Authors: Kearney, MichèlePerron, JulieMarc, IsabelleWeisnagel, S. JohnTchernof, AndréRobitaille, Julie
Abstract: The aim of this cohort study was to compare body composition and regional body fat distribution between children exposed (GDM+) or unexposed (GDM−) in utero to gestational diabetes mellitus (GDM) and to investigate the association with the glycaemic and the insulin profile. Data from 56 GDM+ and 30 GDM− were analysed. Height, weight and waist circumference were measured. Total and regional body composition was measured by dual-energy X-ray absorptiometry. Insulin, glucose and HbA1c were obtained from a fasting plasma sample, and the HOMA-IR index was calculated. anova was performed to compare adiposity measures between GDM+ and GDM−. Associations between the glycaemic and insulin profile and adiposity measures were studied using partial Pearson correlations. Mean age was 6.6 ± 2.3 years. Waist circumference, fat mass percentage, android fat mass, android fat mass percentage and android-to-gynoid fat mass ratio were higher among GDM+, and lean mass percentage was lower (P < 0.05). Among GDM+ children, body mass index (BMI) z score, waist circumference, fat mass percentage, android fat mass percentage and android-to-gynoid fat mass ratio were all positively correlated with HbA1C (r = 0.32–0.43, P < 0.05). Prenatal exposure to GDM is associated with increased total and abdominal adiposity. This increased adiposity observed among GDM+ children is associated with an altered glycaemic profile. This study is registered in the Clinical Trials.gov registry (NCT01340924). What is already known about this subject? • Although body mass index (BMI) is frequently used to assess children adiposity, other anthropometric measures may be better indicators of cardiometabolic risk. • Few studies investigated others adiposity measures in children exposed to gestational diabetes. What this study adds? • In the current study, adiposity of children exposed to gestational diabetes is evaluated in a more complete and precise manner with assessment of body composition and fat distribution by dual-energy X-ray absorptiometry. • This study also investigates the association of those adiposity measures with children glycaemic and insulin profile.
Document Type: Article de recherche
Issue Date: 13 December 2017
Open Access Date: 13 December 2018
Document version: AM
Permalink: http://hdl.handle.net/20.500.11794/16262
This document was published in: Clinical Obesity
https://doi.org/10.1111/cob.12237
Wiley-Blackwell
Alternative version: 10.1111/cob.12237
29239129
Collection:Articles publiés dans des revues avec comité de lecture

Files in this item:
SizeFormat 
Kearney-MainDocument_revised 16_11_2017.pdf604.71 kBAdobe PDFView/Open
All documents in CorpusUL are protected by Copyright Act of Canada.