Role and innocuity of Tisseel ®, a tissue glue, in the grafting process and in vivo evolution of human cultured epidermis

Authors: Auger, François A.Guignard, Rina; López Valle, Carlos Antonio; Germain, Lucie
Abstract: Cultured epidermal sheets are currently used for burn wound treatment but reported results on graft take are variable. This study was designed to evaluate the role and influence of Tisseel®, a fibrin glue, in the take of cultured human epidermal sheets in an athymic mouse model. On days 4, 10 and 21 post-grafting, histology, electron microscopy and immunofluorescence staining confirmed the presence of a human epithelium and the development of a basement membrane. Tisseel® was detectable on day 4 only, but overall treated and untreated grafts were similar. The use of Tisseel® enhanced the mechanical stability of these fragile grafts, increased the percentage of graft take, and its innocuity on thein vivo evolution of cultured epidermal sheets was demonstrated. For these reasons, we think that Tisseel® may be advantageous in a clinical setting.
Document Type: Article de recherche
Issue Date: 14 April 2005
Open Access Date: Restricted access
Document version: VoR
This document was published in: British Journal of Plastic Surgery, Vol. 46 (2), 136–142 (1993)
Churchill Livingstone
Alternative version: 10.1016/0007-1226(93)90145-2
Collection:Articles publiés dans des revues avec comité de lecture

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