From CNTNAP2 to early expressive language in infancy : the mediation role of rapid auditory processing

Authors: Riva, Valentina; Cantiani, Chiara; Benasich, April; Molteni, Massimo; Piazza, Caterina; Giorda, Roberto; Dionne, GinetteMarino, Cecilia
Other Title(s): From CNTNAP2 to language : the mediation role of RAP
Abstract: Although it is clear that early language acquisition can be a target of CNTNAP2, the pathway between gene and language is still largely unknown. This research focused on the mediation role of rapid auditory processing (RAP). We tested RAP at 6 months of age by the use of event-related potentials, as a mediator between common variants of the CNTNAP2 gene (rs7794745 and rs2710102) and 20-month-old language outcome in a prospective longitudinal study of 96 Italian infants. The mediation model examines the hypothesis that language outcome is explained by a sequence of effects involving RAP and CNTNAP2. The ability to discriminate spectrotemporally complex auditory frequency changes at 6 months of age mediates the contribution of rs2710102 to expressive vocabulary at 20 months. The indirect effect revealed that rs2710102 C/C was associated with lower P3 amplitude in the right hemisphere, which, in turn, predicted poorer expressive vocabulary at 20 months of age. These findings add to a growing body of literature implicating RAP as a viable marker in genetic studies of language development. The results demonstrate a potential developmental cascade of effects, whereby CNTNAP2 drives RAP functioning that, in turn, contributes to early expressive outcome.
Document Type: Article de recherche
Issue Date: 11 May 2017
Open Access Date: 11 May 2018
Document version: AM
This document was published in: Cerebral cortex, Vol. 27 (5), 1-30 (2017)
Oxford University Press
Alternative version: 10.1093/cercor/bhx115
Collection:Articles publiés dans des revues avec comité de lecture

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