Dobutamine stress echocardiography in healthy adult male rats

DC FieldValueLanguage
dc.contributor.authorPlante, Éric-
dc.contributor.authorLachance, Dominic-
dc.contributor.authorDrolet, Marie-Claude-
dc.contributor.authorRoussel, Élise-
dc.contributor.authorCouët, Jacques-
dc.contributor.authorArsenault, Marie-
dc.date.accessioned2017-11-15T16:29:41Z-
dc.date.available2017-11-15T16:29:41Z-
dc.date.issued2005-10-26-
dc.identifier.issn1476-7120fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/15862-
dc.description.abstractBackground : Dobutamine stress echocardiography is used to investigate a wide variety of heart diseases in humans. Dobutamine stress echocardiography has also been used in animal models of heart disease despite the facts that the normal response of healthy rat hearts to this type of pharmacological stress testing is unknown. This study was performed to assess this normal response. Methods : 15 normal adult male Wistar rats were evaluated. Increasing doses of dobutamine were infused intravenously under continuous imaging of the heart by a 12 MHz ultrasound probe. Results : Dobutamine stress echocardiography reduced gradually LV diastolic and systolic dimensions. Ejection fraction increased by a mean of +24% vs. baseline. Heart rate increased progressively without reaching a plateau. Changes in LV dimensions and ejection fraction reached a plateau after a mean of 4 minutes at a constant infusion rate. Conclusion : DSE can be easily performed in rats. The normal response is an increase in heart rate and ejection fraction and a decrease in LV dimensions. A plateau in echocardiographic measurements is obtained after 4 minutes of a constant infusion rate in most animals.fr
dc.languageengfr
dc.publisherBioMed Centralfr
dc.subjectDobutaminefr
dc.subjectStress echocardiographyfr
dc.subjectRatfr
dc.subjectAnimal modelfr
dc.subjectStressfr
dc.titleDobutamine stress echocardiography in healthy adult male ratsfr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationCardiovascular ultrasound, Vol. 3 (34), 1-7 (2005)fr
dc.identifier.doi10.1186/1476-7120-3-34fr
dc.identifier.pubmed1276802fr
dc.subject.rvmÉchocardiographie de stressfr
dc.subject.rvmRats (Animaux de laboratoire)fr
rioxxterms.versionVersion of Recordfr
rioxxterms.version_of_recordhttps://doi.org/10.1186/1476-7120-3-34fr
rioxxterms.project.funder_nameCanadian Institutes of Health Researchfr
rioxxterms.project.funder_nameHeart and Stroke Foundation of Canadafr
rioxxterms.project.funder_nameQuebec Heart Institute Corporationfr
bul.rights.periodeEmbargo0 moisfr
Collection:Articles publiés dans des revues avec comité de lecture

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