Moderate exercise training improves survival and ventricular remodeling in an animal model of left ventricular volume overload.

DC FieldValueLanguage
dc.contributor.authorLachance, Dominic-
dc.contributor.authorPlante, Éric-
dc.contributor.authorChampetier, Serge-
dc.contributor.authorRoussel, Élise-
dc.contributor.authorDrolet, Marie-Claude-
dc.contributor.authorArsenault, Marie-
dc.contributor.authorCouët, Jacques-
dc.date.accessioned2017-11-15T14:35:33Z-
dc.date.available2017-11-15T14:35:33Z-
dc.date.issued2009-09-15-
dc.identifier.issn1941-3289fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/15839-
dc.description.abstractBACKGROUND: Exercise training has beneficial effects in patients with heart failure, although there is still no clear evidence that it may impact on their survival. There are no data regarding the effects of exercise in subjects with chronic left ventricular (LV) volume overload. Using a rat model of severe aortic valve regurgitation (AR), we studied the effects of long-term exercise training on survival, development of heart failure, and LV myocardial remodeling. METHODS AND RESULTS: One hundred sixty male adult rats were divided in 3 groups: sham sedentary (n=40), AR sedentary (n=80), and AR trained (n=40). Training consisted in treadmill running for up to 30 minutes, 5 times per week for 9 months, at a maximal speed of 20 m/minute. All sham-operated animals survived the entire course of the protocol. After 9 months, 65% of trained animals were alive compared with 46% of sedentary ones (P=0.05). Ejection fractions remained in the normal range (all above 60%) and LV masses between AR groups were similar. There was significantly less LV fibrosis in the trained group and lower LV filling pressures and improved echocardiographic diastolic parameters. Heart rate variability was also improved by exercise. CONCLUSIONS: Our data show that moderate endurance training is safe, does not increase the rate of developing heart failure, and most importantly, improves survival in this animal model of chronic LV volume overload. Exercise improved LV diastolic function, heart rate variability, and reduced myocardial fibrosis.fr
dc.languageengfr
dc.publisherLippincott Williams & Wilkinsfr
dc.subjectSurvivalfr
dc.subjectExercisefr
dc.subjectHypertrophyfr
dc.subjectValvesfr
dc.subjectCollagenfr
dc.titleModerate exercise training improves survival and ventricular remodeling in an animal model of left ventricular volume overload.fr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationCirculation : Heart Failure, Vol. 2 (5), 437–445 (2009)fr
dc.identifier.doi10.1161/CIRCHEARTFAILURE.108.845487fr
dc.identifier.pubmed19808374fr
dc.subject.rvmRemodelage ventriculairefr
dc.subject.rvmCœur -- Ventricule gauche -- Hypertrophiefr
dc.subject.rvmExercice -- Aspect physiologiquefr
dc.subject.rvmCollagènefr
dc.subject.rvmRats (Animaux de laboratoire)fr
rioxxterms.versionAccepted Manuscriptfr
rioxxterms.version_of_recordhttps://doi.org/10.1161/CIRCHEARTFAILURE.108.845487fr
rioxxterms.projectMOP-61818fr
rioxxterms.project.funder_nameCanadian Institutes of Health Researchfr
bul.rights.periodeEmbargo6 moisfr
Collection:Articles publiés dans des revues avec comité de lecture

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